0081 The impact of sleep deficiency on spatial working and long-term memory in different rat models of sleep deprivation

Abstract Introduction A pressing issue in modern society, lack of sleep has detrimental health consequences, among which cognitive dysfunctions attract great attention. Although there is consensus about the harmful effects insufficient on vigilance and attention, still a debate memory susceptibility to acute chronic deprivation. Which types are more vulnerable remains unclear. We studied spatial working long-term deprivation rats. Methods Male Wistar rats were deprived (SD) by placing cages an orbital shaker. Animals subjected three patterns SD: 1) SD (ASD) — continuous for 18 hours; 2) short restriction (SSR) —cycles 3-hour followed 1 hour opportunity over 24 hours, with total duration 3) (CSR) SSR 5 consecutive days. For each protocol, was assessed spontaneous alternation test Y-maze. Learning Barnes maze test. Results ASD impaired memory, as alternations Y-maze test, decreased level locomotion/exploration (assessed number arm entries). However, CSR, 1-hour alternating opportunities allowed preventing loss. The demonstrated no changes learning or under any tested conditions. Conclusion results suggest that most Even 5-day restriction, negative effect disappears if during intermittent intervals. It indicates importance intervals protect against sustained restriction. resilience conditions implies short-term systems diverge their deficiency. Support (if any) State assignment Institute Evolutionary Physiology Biochemistry; theme reg. no. АААА-А18-118012290427-7.